Design, synthesis and antitubercular activity of compounds containing aryl and heteroaryl groups with alkylaminoethyl chains
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Panda, Gautam
Parai, M K Srivastava, A K Chaturvedi, Vinita Manju, Y K Sinha, Sudhir |
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| Date |
2010-09-09T08:51:29Z
2010-09-09T08:51:29Z 2009 |
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| Identifier |
Indian Journal of Chemistry, 48B, 2009, 1121-1127
http://hdl.handle.net/123456789/583 |
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| Description |
Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-25 g/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubercular activity. Among heteroaryl containing triarylmethanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.
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| Format |
154958 bytes
application/pdf |
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| Language |
en
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| Subject |
Tuberculosis
TB bacterial infection Mycobacterium tuberculosis alkylaminoethyl chains antitubercular activity mycobacteria TRAM |
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| Title |
Design, synthesis and antitubercular activity of compounds containing aryl and heteroaryl groups with alkylaminoethyl chains
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| Type |
Article
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