A new synthetic route to unsymmetrical 9-arylxanthenes
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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Creator |
Das, S K
Singh, Ritesh Panda, Gautam |
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Date |
2010-09-09T08:51:39Z
2010-09-09T08:51:39Z 2009 |
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Identifier |
Eur. J. Org. Chem. 2009, 4757–4761
http://hdl.handle.net/123456789/584 |
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Description |
A facile and general three-step synthetic route towards unsymmetrical 9-arylxanthenes has been developed. The reaction sequence involves nucleophilic substitution reaction of commercially available 2-fluorobenzaldehydes with arenoxides, Grignard reaction of the resulting 2-arenoxybenzaldehydes with arylmagnesium bromides followed by 10 mol% FeCl3 catalyzed intramolecular diarylmethylation of the resulting carbinols. This strategy was extended to access symmetrical as well as unsymmetrical 9-arylthioxanthenes.
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Format |
123538 bytes
application/pdf |
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Language |
en
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Subject |
xanthene
thioxanthene intramolecular friedel crafts reaction unsymmetrical |
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Title |
A new synthetic route to unsymmetrical 9-arylxanthenes
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Type |
Article
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