Synthetic studies towards steroid-amino acid hybrids
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Shagufta
Singh, Ritesh Panda, Gautam |
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| Date |
2010-09-09T08:52:11Z
2010-09-09T08:52:11Z 2009 |
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| Identifier |
Ind. J. Chem. 48B (7), 2009, 989-995
http://hdl.handle.net/123456789/587 |
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| Description |
New prototype of natural steroid amino acid hybrid containing nine membered D-ring in the steroid skeleton has been synthesized from commercially available estrone using standard synthetic organic transformations. NaIO4 cleavage of the D-ring of the benzylated estriol furnishes the D-seco diol 8, which after a series of organic reactions (protection of the hydroxyl group, oxidation, reductive amination, deprotection and the Yamaguchi cross coupling) gives the coveted steroid-amino acid hybrids. The methodology can be extended for combinatorial synthesis of new and interesting steroid amino acid hybrids.
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| Format |
155759 bytes
application/pdf |
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| Language |
en
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| Subject |
Steroid
amino acids hybrid Yamaguchi coupling macrolactonization |
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| Title |
Synthetic studies towards steroid-amino acid hybrids
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| Type |
Article
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