Derivatives of human beta-Casein fragments (54-59) exhibit highly potent immunosuppressant activity.
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Puri, A
Bhattacharya, M Tripathi, L M Haq, W |
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| Date |
2010-09-09T08:52:31Z
2010-09-09T08:52:31Z 2009 |
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| Identifier |
International Immunopharmacology, 9 (9) 2009, 1092-1096
http://hdl.handle.net/123456789/589 |
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| Description |
Human β-casein fragment (54-59) having the amino acid sequence Val-Glu-Pro-Ile-Pro-Tyr, has shown potent immunostimulant activity. Several analogs of this hexapeptide have been synthesized with modification at the N-terminal region and two analogs, viz. peptide I and peptide II have shown significant immunosuppressant activity in-vivo mouse model. Effect on cell mediated immunity (CMI) and humoral immunity was studied in mouse/SRBC model. Both the peptides failed to stimulate immune response in vivo and showed inhibition of CMI and humoral response to sheep red blood cells (SRBC). Peptides showed inhibition in alloantigen induced lymphocyte proliferation, i.e., mixed lymphocyte reaction (MLR) in vitro. Treatment with peptides inhibited the production of interferon-γ (IFN-γ), and increased the production of interleukin-4 (IL-4) as well as improved the skin graft survival. Cyclosporine a known immunosuppressant showed similar effect on mouse model. Present study thus provides a lead for the development of safe and effective immunosuppressant.
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121401 bytes
application/pdf |
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| Language |
en
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| Subject |
human beta-casein fragments
Immunosuppressant peptide immunomodulator Lymphocytes proliferation |
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| Title |
Derivatives of human beta-Casein fragments (54-59) exhibit highly potent immunosuppressant activity.
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| Type |
Article
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