Application of the modified Pictet-Spengler cyclization reaction for the preparation of imidazopyrazine ring: Synthesis of new pyrido- and pyrimido-imidazopyrazines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sharma, Sunil
Kundu, Bijoy |
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| Date |
2010-09-09T08:57:12Z
2010-09-09T08:57:12Z 2009 |
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| Identifier |
J Comb Chem. 2009, 11(4), 720-31
http://hdl.handle.net/123456789/605 |
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| Description |
An efficient and versatile method for the synthesis of imidazopyrazine ring using the modified Pictet-Spengler strategy has been reported. The two step strategy offers rapid assembly of drug-like core templates pyridine or pyrimidine and imidazole into new annulated polycyclic skeletons: pyrido- and pyrimido-imidazopyrazines. The rate of endo cyclization of aryl/heteroaryl- amine substrates have been compared with traditionally used aliphatic amine substrates and results have been discussed in the light of the pKa values of amines present in each substrate.
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| Format |
222157 bytes
application/pdf |
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| Language |
en
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| Subject |
Pictet Spengler reaction
cyclization privileged structures N-rich polycycles fused-ring systems |
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| Title |
Application of the modified Pictet-Spengler cyclization reaction for the preparation of imidazopyrazine ring: Synthesis of new pyrido- and pyrimido-imidazopyrazines
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| Type |
Article
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