Reporter genes facilitating discovery of drugs targeting protozoan parasites
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive InfoField | Value | |
Creator |
Dube, Anuradha
Gupta, Reema Singh, Nasib |
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Date |
2010-09-20T11:10:44Z
2010-09-20T11:10:44Z 2009 |
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Identifier |
Trends in Parasitology, 2009, 25(9), 432-9
http://hdl.handle.net/123456789/609 |
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Description |
Transfection of protozoan parasites, such as Plasmodium, Leishmania, Trypanosoma and Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand the biology of the host–parasite interactions at the cellular level. It has provided impetus to the development of rapid and reliable drug screens for both established drugs and new molecules against different parasites and other pathogens. Furthermore, reporter genes have proved to be an excellent and promising tool for studying disease progression including imaging. Here, we review the recent advances made by using reporter genes for in-vitro and in-vivo drug screening, high-throughput screening, whole-animal non-invasive imaging for parasites and for the study of several aspects of host–parasite interactions.
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805804 bytes
application/pdf |
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Language |
en
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Subject |
Plasmodium
Leishmania Trypanosoma Toxoplasma antileishmanial antimalarial |
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Title |
Reporter genes facilitating discovery of drugs targeting protozoan parasites
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Type |
Article
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