Anti-dyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Kumar, Abdhesh Bhatia, Gitika Khan, M M Khanna, A K Saxena, J K |
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| Date |
2010-10-04T09:16:08Z
2010-10-04T09:16:08Z 2009 |
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| Identifier |
Eur J Med Chem. 2009, 44(4),1813-8
http://hdl.handle.net/123456789/616 |
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| Description |
8-hydroxyquinoline when subjected to duff reaction resulted in the formation of unexpected 7-methylaminomethylene-8-oxo-7, 8-dihydroquinoline-5-carbaldehyde 2, which existed in the keto- enamine form, in which the aromaticity of the relevant ring was disrupted, which upon subsequent treatment with various primary amines resulted in its nucleophilic substitution of aliphatic methyl amine.These interesting novel derivatives were evaluated in vitro for their antioxidant and in vivo for their antidyslipidemic and post heparin lipolytic activity. Compound 6 was found to be most active antidyslipidemic and antioxidative agent in this series respectively, and thus represent a new class of promising lead.
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174172 bytes
application/pdf |
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| Language |
en
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| Subject |
Keto-Enamine Schiff bases
8-hydroxyquinoline Antioxidant Lipid lowering activity |
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| Title |
Anti-dyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases
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| Type |
Article
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