Functional and Structural characterization of ADF/cofilin homologue from Leishmania donovani.
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Tammana, T V S
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| Date |
2010-10-07T06:49:30Z
2010-10-07T06:49:30Z 2010-10-07T06:49:30Z |
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| Identifier |
http://hdl.handle.net/123456789/624
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| Description |
Ph D Thesis submitted to JNU New Delhi in 2009.
ADF/cofilin family of proteins is ubiquitously present in all eukaryotes. Metazoans have two or more members of this group of proteins, yeast and amoeba express only one member of ADF/cofilin family (Ono, 2007). These small molecular mass proteins regulate actin dynamics in a variety of ways. Various in-vitro studies have shown that ADF/cofilin accelerate actin monomer dissociation from pointed ends which adds in to the monomer pool of actin (Bamburg, 1999; Carlier et al., 1999; Pollard et al., 2000). ADF/cofilin also exhibit weak actin filament severing activity which generates new barbed ends and facilitate rapid increase in filament assembly at the leading edge (Maciver et al., 1991; Ono, 2003). These activities have recently been shown to depend on the concentration of ADF/cofilin proteins (Andrianantoandro and Pollard 2006). |
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12271563 bytes
application/pdf |
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| Language |
en
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T-36
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| Subject |
eukaryotes
Metazoans Gupta , C M |
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| Title |
Functional and Structural characterization of ADF/cofilin homologue from Leishmania donovani.
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| Type |
Thesis
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