Antimicrobial Evaluation of Clerodane Diterpenes from Polyalthia longifolia var. pendula
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Sashidhara, K V
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| Date |
2010-12-11T07:25:44Z
2010-12-11T07:25:44Z 2009 |
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| Identifier |
Nat Prod Commun. 2009, 4(3), 327-30
http://hdl.handle.net/123456789/639 |
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| Description |
Phytochemical investigation of the ethanolic extract of leaves of Polyalthia longifolia var. pendula has led to the isolation of seven clerodane diterpenoids and five alkaloids. (-)-14, 15-bisnor-3, 11E-kolavadien-13-one (1), (-)-16-oxocleroda-3,13(14)E-dien-15-oic acid (2), (-)-16α-hydroxycleroda-3,13 (14)Z-dien-15,16-olide (3), (+)-(4→2)-abeo-16(R/S)-2, 13Z-kolavadien-15, 16-olide-3-al (4), (-)-3β, 16α-dihydroxycleroda-4(18), 13(14)Z-dien-15,16-olide (5), (-)-3, 12E-kolavadien-15-oic acid-16-al (6), (-)-labd-13E-en-8-ol-15-oic acid (7), liriodenine (8), (-)-anonaine (9), (+)-isoboldine (10), (-)-asimilobine (11) and hordenine (12) have been isolated. This is the first report of 1, 6 and 10 from this plant species while 12 is reported for first time from this genus. Clerodane derivatives 1-7 were evaluated for their antimicrobial activity. Diterpene 3 was found to be most potent agent with MIC value of 6.25 μg/mL against Staphylococcus aureus and Sporothrix schenckii.
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147548 bytes
application/pdf |
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| Language |
en
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| Subject |
Polyalthia longifolia var. pendula
clerodane diterpenes aporphine alkaloids |
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| Title |
Antimicrobial Evaluation of Clerodane Diterpenes from Polyalthia longifolia var. pendula
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| Type |
Article
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