Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Kumar, Abdhesh Kumar, Manoj Srivastava, Anuj Puri, Anju |
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| Date |
2010-12-11T07:25:21Z
2010-12-11T07:25:21Z 2010 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters 20 (2010) 6504–6507
http://hdl.handle.net/123456789/636 |
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| Description |
A series of novel coumarin bisindole heterocycles were synthesized following an uncommon method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 12 compounds tested, the compound 5e showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels (TG) by 55%, total cholesterol (TC) by 20%, accompanied by an increase in HDL-C/TC ratio by 42% in hyperlipidemic rats to a greater degree than some of the reference statins.
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| Format |
248232 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 7953
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| Subject |
Synthesis
Coumarin Indole Statins Cholesterol lowering Hypolipidemic Agents |
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| Title |
Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives
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| Type |
Article
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