Synthesis and Biological Evaluation of Indolyl Glyoxylamides as a new class of Antileishmanial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Chauhan, S S
Gupta, Leena Mittal, Monika Vishwakarma, Preeti Gupta, Suman Chauhan, P M S |
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| Date |
2010-12-11T07:21:11Z
2010-12-11T07:21:11Z 2010 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters 20 (2010) 6191–6194
http://hdl.handle.net/123456789/633 |
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| Description |
A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of L. donovani. Compound 8c has been identified as the most active analog of the series with IC50 value of 5.17 µM and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine
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| Format |
154839 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 7952
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| Subject |
Antileishmanial
Indolylglyoxylamides Tetrahydro-β-carboline |
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| Title |
Synthesis and Biological Evaluation of Indolyl Glyoxylamides as a new class of Antileishmanial agents
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| Type |
Article
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