Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Sashidhara, K V
Kumar, Abdhesh Chatterjee, Manavi Rao, K B Singh, S Verma, A K Palit, Gautam |
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| Date |
2011-03-22T10:58:11Z
2011-03-22T10:58:11Z 2010 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters, 21(7), 11, 1937-41
http://hdl.handle.net/123456789/658 |
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| Description |
A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited impressive antidepressant activity, measured in terms of percentage decrease in immobility duration (% DID). In addition, the active antidepressant compounds were subsequently studied at their most effective dose and activity of these compounds were confirmed in forced swimming test (FST) animal model, in which the compounds at a low dose of 0.5 mg/kg significantly decreased the immobility time and exhibited greater efficacy than the reference standards fluoxetine and imipramine. The potent compounds did not show any neurotoxicity in the rotarod test and the preliminary results are promising enough to warrant further studies around this scaffold.
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176713 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 8026
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| Subject |
Synthesis
Coumarin Antidepressant Activity Forced Swim Test Tail Suspension Test |
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| Title |
Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
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| Type |
Article
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