Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Kumar, Abdhesh Kumar, Manoj Sarkar, Jayanta Sinha, S |
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| Date |
2011-05-13T08:38:55Z
2011-05-13T08:38:55Z 2010 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters, 20(24), 7205-7211
http://hdl.handle.net/123456789/663 |
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| Description |
A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 & 26) showed IC50 range in between 3.59 to 17.97 µM. The most promising compound 26 showed around 30 fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC50 value of 3.59 µM.
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| Format |
207680 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 7961
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| Subject |
Synthesis
Coumarin Chalcone in vitro Cytotoxicity |
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| Title |
Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents
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| Type |
Article
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