Aza-Annulation on the 16-dehydropregnenolone, via tandem intermolecular Aldol process and intramolecular Michael addition
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Kumar, Manmeet
Rawat, Preeti Khan, M F Rawat, A K Srivastava, A K Maurya, Rakesh |
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| Date |
2011-07-15T08:49:16Z
2011-07-15T08:49:16Z 2011 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters (2011), 21(8), 2232-37
http://hdl.handle.net/123456789/703 |
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| Description |
16-Dehydropregnenolone undergoes a smooth annulation with propan-1-amine and aromatic aldehydes. Several amine derivatives of 16- dehydropregnenolone were synthesized and evaluated as inhibitors of DPP-IV. The structures of compounds were confirmed by 1H, 13C, NMR and mass spectral analysis. Among seventeen compounds evaluated only five compounds 1, 9, 13, 15 and 16 demonstrated significant inhibition of DPP. This study suggest that introduction of appropriate substituents in the 16-Dehydropregnenolone plays an important role in DPP-IV inhibitory activity.
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| Format |
184892 bytes
application/pdf |
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| Language |
en
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| Subject |
16-Dehydropregnenolone
Annulation DPP-IV Gene Cyclisation |
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| Title |
Aza-Annulation on the 16-dehydropregnenolone, via tandem intermolecular Aldol process and intramolecular Michael addition
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| Type |
Article
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