Study of Conformation and DNA Binding Specificity of Transcription Factors
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Study of Conformation and DNA Binding Specificity of Transcription Factors
|
|
| Creator |
Raha, Paromita
|
|
| Subject |
Structural Biology & Bioinformatics
|
|
| Description |
The regulation of gene expression in bacteria primarily occurs at the level of transcription initiation. In bacterial chromosomes, a transcription unit (TU) is the ordered assembly of: a regulatory region, a transcription start site, one or more open reading frames (ORFs)
and a transcription termination site. When a TU comprises more than one ORF, the transcribed mRNA is called polycistronic; otherwise, it is called monocistronic. The
collection of overlapping TUs constitutes an operon. Even in a polycistronic TU, it has been observed that operons always contain a single promoter that transcribes the whole
set of genes conforming its TUs. The regulatory region contains cis elements such as the promoter – where the RNA polymerase initially binds – and transcription factor-binding sites (TFBS) – where transcription factors (TFs) bind to modulate the binding of the RNA polymerase (Browning, D.F. et al., 2004). It is now becoming clear that long non-coding RNA genes can have numerous molecular functions, like modulating transcriptional patterns, regulating protein activities, serving structural or organizational roles, altering RNA processing events, and serving as precursors to small RNAs.
|
|
| Date |
2009
|
|
| Type |
Thesis
NonPeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/938/1/Paromita_Raha_Thesis.pdf
Raha, Paromita (2009) Study of Conformation and DNA Binding Specificity of Transcription Factors. PhD thesis, Calcutta University. |
|
| Relation |
http://www.eprints.iicb.res.in/938/
|
|