A Phaseolinone new Antileishmanial Compound.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A Phaseolinone new Antileishmanial Compound.
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| Creator |
Roy, Rabindra
Bhattacharyya, Gautam Siddique, K A I Bhadra, Ranjan |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Inclusion of phaseolinone, a newly described mycotoxin, at
20 pg’ per ml in a solid culture medium (blood agar overlay) and at 5Opg
per ml in a liquid culture (medium 199) inhibited the growth of L. -d.o novani
promastigotes. About 90% of the motile promastigotes lost -motility
after exposure to 50 pg per ml of phaseolinone for 6-7 h and here 3-
day-old culture was more sensitive than 7-day-old culture. In an in vitro
assay, DNA dependent RNA polymerase activity of 3-day-old promazis
was considerably inhibited in the presence of this toxin. Therefore,
this key enzyme was suggested to be one of the sites of action of phaseolinone.
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| Publisher |
Elsevier
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/939/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS_168_(1)_51%2D57;1990[46].pdf
Roy, Rabindra and Bhattacharyya, Gautam and Siddique, K A I and Bhadra, Ranjan (1990) A Phaseolinone new Antileishmanial Compound. Biochemical and Biophysical Research Communications, 168 (1). pp. 43-50. |
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| Relation |
http://dx.doi.org/10.1016/0006-291X(90)91672-F
http://www.eprints.iicb.res.in/939/ |
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