Signaling Events Involved in Manipulatin Macrophage Defense Machinery by Natural Immunomodulators Using Visceral Leishmaniasis as Model Macrophage Disease
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Signaling Events Involved in Manipulatin Macrophage Defense Machinery by Natural Immunomodulators Using Visceral Leishmaniasis as Model Macrophage Disease
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| Creator |
Kar, Susanta
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| Subject |
Infectious Diseases and Immunology
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| Description |
Macrophages are the major differentiating cells of the mononuclear phagocyte system, which comprises bone marrow monoblast and promonoblast, peripheral monocytes
and tissue macrophages. Metchnikoff was the first to use the term “macrophages” (i.e. big eaters), capable of ingesting large particles such as erythrocytes, sparmatozoa, protozoa etc., as opposed to the polymorphonuclear leukocytes or granulocytes,
which he termed ‘microphages’ since these cells are capable of taking only small particles (e.g. bacteria).
During haematopoiesis in the bone marrow (Fig. 1), cells of the mononuclear phagocyte system originate
from a pluripotent stem cell and differentiate
under the influence of specific signals (Golde and Gasson, 1988) through several intermediary stages to mature macrophages. Topological factors seem to influence their final destination and to endow each type with particular metabolic and structural features. Besides the widely recognised functions in primary defense system involved in inflammation and clearance of invading agents,
macrophages also play a significant role in inducing and regulating the immune response by taking protein antigens and generating immunogenic fragments from them (Unanue and
Allen, 1987). Their widespread dispersal during early and adult life, versatile biosynthetic activities of well defined products (Takemura and Werb, 1984), possession of specific surface receptors and remarkable responsiveness to local environmental influences (Mokoena and Gordon, 1986) endow these cells with the ability to interact with many cells and molecules of the body in health and disease.
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| Date |
2009
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/942/1/Susanta_Kar_Thesis.pdf
Kar, Susanta (2009) Signaling Events Involved in Manipulatin Macrophage Defense Machinery by Natural Immunomodulators Using Visceral Leishmaniasis as Model Macrophage Disease. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/942/
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