Phasjzolinone, a new Mycotoxin, Inhibits RNA Polyyerase(s) other Than rna Polymerase II
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Phasjzolinone, a new Mycotoxin, Inhibits RNA Polyyerase(s)
other Than rna Polymerase II
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| Creator |
Bhattacharyya, Goutam
Roy, Amit Siddique, K A I Bhadra, Ranjan |
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| Subject |
Infectious Diseases and Immunology
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| Description |
DNA-dependent RNA synthesis in an isolated rat liver nuclei -i n
vitro assay was inhibited by 41 and 61% in the presence of ff-amanitin,
the inhibitor specific for RNA polymerase II and phaseolinone, a new
mycotoxin, respectively. This inhibition reached 97% when these two
inhibitors were present together. The RNA polymerase activity present
in a nucleolar fraction was inhibited by greater than 80% in presence
of phaseolinone, but phaseolinone and DNA showed no interaction as judged
from CD spectra or density gradient centrifugation of toxin-treated DNA.
This evidence suggested that phaseolinone inhibited RNA polymerase activity
other than RNA polymerase II.
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| Publisher |
Elsevier
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/947/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS_168_(1)_51%2D57;1990[46].pdf
Bhattacharyya, Goutam and Roy, Amit and Siddique, K A I and Bhadra, Ranjan (1990) Phasjzolinone, a new Mycotoxin, Inhibits RNA Polyyerase(s) other Than rna Polymerase II. Biochemical and Biophysical Research Communications, 168 (1). pp. 51-57. |
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| Relation |
http://dx.doi.org/10.1016/0006-291X(90)91673-G
http://www.eprints.iicb.res.in/947/ |
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