Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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Title |
Infection of Human Mononuclear Phagocytes and
Macrophage-Like THP1 Cells with Leishmania
donovani Results in Modulation of Expression of a
Subset of Chemokines and a Chemokine Receptor
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Creator |
Dasgupta, B
Roychoudhury, K Ganguly, S Akbar, M A Das, P Roy, Syamal |
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Subject |
Cancer Biology and Inflammatory Disorder Division
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Description |
The expression of chemokines and chemokine receptors was studied in
Leishmania donovani (LD)-infected human mononuclear phagocytes and the
human monocytic cell line THP1. Our studies showed that LD infection caused
the upregulation of three b chemokines (macrophage inflammatory protein-1
alpha (MIP-1a), MIP-1b and RANTES (regulated on activation normal T cell expressed and secreted)), one a chemokine (interleukin-8 (IL-8)) and the CC chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase- polymerase chain reaction (RT-PCR) analysis. The CCR5 upregulation in human mononuclear phagocytes and THP1 cells was also evident by confocal microscopy. The possible association of such upregulation in relation to Leishmania and human immunodeficiency virus (HIV) coinfection was discussed.
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Date |
2003
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://www.eprints.iicb.res.in/949/1/SCANDINAVIAN_JOURNAL_OF_IMMUNOLOGY%2C_57(_4)%2C366%2D374[70].pdf
Dasgupta, B and Roychoudhury, K and Ganguly, S and Akbar, M A and Das, P and Roy, Syamal (2003) Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor. Scandinavian Journal of Immunology, 57 (4). pp. 366-374. |
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Relation |
http://dx.doi.org/10.1046/j.1365-3083.2003.01227.x
http://www.eprints.iicb.res.in/949/ |
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