Acivlcin : A Highly Active Potential Chemotherapeutic Agent against Visceral Leishmaniasis.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Acivlcin : A Highly Active Potential Chemotherapeutic Agent against Visceral Leishmaniasis.
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| Creator |
Mukherjee, Tanmoy
Roy, Krishnendu Bhaduri, Amar Nath |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Acivicin, a chlorinated amino acid antibiotic, is found to be
remarkably effective in killing both the vector and the host form of
the parasitic protozoa, Leishmania donovani, the causative agent for visceral
leishmaniasis or Kala-azar. The ED50 (50 nM1 for the pathogenic
amastigote form in invitro screening system is significantly lower than
the reported values for other drugs under trial. The drug irreversibly
inactivates both in vitro and in vivo carbamyl phosphate synthetase II,
the first enzyme of the pyrimidine biosynthetic pathway. The irreversible
inactivation of this sensitive target enzyme and lack of effective
reversal by glutamine makes acivicin a preferred candidate for potential
chemotherapy against increasing number of Kala-azar cases that are reported
to be unresponsive to pentavalent antimonials.
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| Publisher |
Elsevier
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/952/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__170(_2)_426%2D432;1990[25].pdf
Mukherjee, Tanmoy and Roy, Krishnendu and Bhaduri, Amar Nath (1990) Acivlcin : A Highly Active Potential Chemotherapeutic Agent against Visceral Leishmaniasis. Biochemical and Biophysical Research Communications, 170 (2). pp. 426-432. |
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| Relation |
http://dx.doi.org/10.1016/0006-291X(90)92109-D
http://www.eprints.iicb.res.in/952/ |
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