Synthesis, Cytotoxicity, and Structure–Activity Relationship (SAR) Studiesn of Andrographolide Analogues as Anti-Cancer Agent
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synthesis, Cytotoxicity, and Structure–Activity Relationship (SAR) Studiesn of Andrographolide Analogues as Anti-Cancer Agent
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| Creator |
Das, Bimolendu
Chowdhury, Chinmay Kumar, Deepak Sen, Rupashree Roy, Rajneeta Das, Padma Chatterjee, Mitali |
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| Subject |
Cell Biology & Physiology
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| Description |
A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14
hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the
analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure–activity relationship
(SAR) revealed that the a-alkylidene-c-butyrolactone moiety of andrographolide played a major role in
the activity profile. The structures of the analogues were established through spectroscopic and analytical
data
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/964/1/7_bmcl_2010.pdf
Das, Bimolendu and Chowdhury, Chinmay and Kumar, Deepak and Sen, Rupashree and Roy, Rajneeta and Das, Padma and Chatterjee, Mitali (2010) Synthesis, Cytotoxicity, and Structure–Activity Relationship (SAR) Studiesn of Andrographolide Analogues as Anti-Cancer Agent. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 6947-6950. |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2010.09.126
http://www.eprints.iicb.res.in/964/ |
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