GC-Rich Intra-Operonic Spacers in Prokaryotes: Possible Relation to Gene Order Conservation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
GC-Rich Intra-Operonic Spacers in Prokaryotes: Possible Relation to Gene Order Conservation
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| Creator |
Dutta, Anirban
Paul, Sandip Dutta, Chitra |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
Genome-scale compositional analyses of non-coding sequences from 410 microbes of varying
GC-content, lineage, environment/life-style, reveal presence of a distinct trend in GC-usage in
spacers between intra-operonic and extra-operonic gene-pairs. For most of the microbes, average
GC-content of the intra-operonic spacers are consistently higher than those between extra-operonic
unidirectional gene-pairs. Also, unidirectional gene-pairs exhibiting higher cross-species conservation,
irrespective of their operonic context, house relatively GC-rich spacers. A few prokaryotes,
most of which represent known cases of genome degradation, stand out as exceptions defying this
trend. GC-enrichment of intra-operonic spacers therefore appears to be an evolutionary strategy
facilitating preservation of operonic gene-order.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/967/1/8_febs_2010.pdf
Dutta, Anirban and Paul, Sandip and Dutta, Chitra (2010) GC-Rich Intra-Operonic Spacers in Prokaryotes: Possible Relation to Gene Order Conservation. FEBS Letters, 584 (22). pp. 4633-4638. |
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| Relation |
http://dx.doi.org/10.1016/j.febslet.2010.10.037
http://www.eprints.iicb.res.in/967/ |
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