Identification of a Sulfonoquinovosyldiacylglyceride from Azadirachta Indica and Studies on its Cytotoxic Activity and DNA Binding Properties
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Identification of a Sulfonoquinovosyldiacylglyceride from Azadirachta Indica and Studies on its Cytotoxic Activity and DNA Binding Properties
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| Creator |
Chatterjee, Ratna
Singh, Omkar Pachuau, Lalawmpuii Malik, Shiba Prasad Paul, Mausumi Bhadra, Kakali Paul, Santanu Kumar, G Suresh Mondal, Nirup B Banerjee, Sukdeb |
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| Subject |
Chemistry
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| Description |
Chromatographic separation of the methanolic extract of the leaves of Azadirachta indica led to the isolation
of a sulfonoglycolipid characterized as a sulfonoquinovosyldiacylglyceride (SQDG), by extensive
2D NMR and mass spectral analysis. SQDG induces apoptosis in a dose dependent manner with IC50
8.3 lM against acute lymphoblastic leukemia (ALL) MOLT-4 cell lines. The compound showed significant
DNA binding properties as evidenced by the enhancement of melting temperature and perturbation of
the characteristic B-form in CD evidence of calf thymus DNA. The DNA binding was also characterized
by isothermal calorimetry where a predominantly enthalpy driven binding to CT DNA was revealed.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/969/1/10_bmcl_2010.pdf
Chatterjee, Ratna and Singh, Omkar and Pachuau, Lalawmpuii and Malik, Shiba Prasad and Paul, Mausumi and Bhadra, Kakali and Paul, Santanu and Kumar, G Suresh and Mondal, Nirup B and Banerjee, Sukdeb (2010) Identification of a Sulfonoquinovosyldiacylglyceride from Azadirachta Indica and Studies on its Cytotoxic Activity and DNA Binding Properties. Bioorganic & Medicinal Chemistry Letters, 20 (22). pp. 6699-6702. |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2010.09.007
http://www.eprints.iicb.res.in/969/ |
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