Intrinsic Molecular Properties of the Protein–Protein Bridge Facilitate Ratchet-Like Motion of the Ribosome
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Intrinsic Molecular Properties of the Protein–Protein Bridge Facilitate Ratchet-Like Motion of the Ribosome
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| Creator |
Shasmal, Manidip
Chakraborty, Biprashekhar Sengupta, Jayati |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
The ribosomal intersubunit bridges maintain the overall architecture of the ribosome and thereby play a
pivotal role in the dynamics of translation. The only protein–protein bridge, b1b, is formed by the two
proteins, S13 and L5 of the small and large ribosomal subunits, respectively. B1b absorbs the largest
movement during ratchet-like motion, and its two proteins reorganize in different constellations during
this motion of the ribosome.
Our results in this study of b1b in the Escherichia coli 70S ribosome suggest that the intrinsic molecular
features of the bridging proteins allow the bridge to modulate the ratchet-like motion in a controlled
manner. Additionally, another large subunit protein, L31, seems to participate with S13 and L5 in the formation,
dynamics, and stabilization of this bridge.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/983/1/25_bbrc_2010.pdf
Shasmal, Manidip and Chakraborty, Biprashekhar and Sengupta, Jayati (2010) Intrinsic Molecular Properties of the Protein–Protein Bridge Facilitate Ratchet-Like Motion of the Ribosome. Biochemical and Biophysical Research Communications, 399 (2). pp. 192-197. |
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| Relation |
http://dx.doi.org/10.1016/j.bbrc.2010.07.053
http://www.eprints.iicb.res.in/983/ |
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