Syntheses, X-ray Crystal Structures, DNA Binding, Oxidative Cleavage Activities and Antimicrobial Studies of Two Cu(II) Hydrazone Complexes
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Syntheses, X-ray Crystal Structures, DNA Binding, Oxidative Cleavage Activities and Antimicrobial Studies of Two Cu(II) Hydrazone Complexes
|
|
| Creator |
Banerjee, Sambuddha
Mondal , Susmita Chakraborty, Writachit Sen, Soma Gachhui, Ratan Ray, J Butcher Slawin, Alexandra M Z Mandal, Chitra Mitra, Samiran |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
From a mononuclear Cu(II)-hydrazone complex [Cu(PBH)2] (1), one l1,1-azido bridged dinuclear Cu(II)
complex having the formula [{Cu(PBH)(l1,1-NNN)}2] (2) (where HPBH = 2-pyridinecarboxaldehyde benzoyl
hydrazone) has been synthesised. Both the complexes are characterised by elemental analyses, IR
and UV–Vis spectroscopic studies. The tridentate hydrazone pro-ligand (HPBH) is obtained by the condensation
of benzhydrazide and pyridine-2-carboxaldehyde. The structures of the complexes have conclusively
been established by the X-ray single crystal diffraction method. Complex 1 and 2 both
display DNA binding ability, which is ascertained by UV–Vis titration and cyclic voltammetric studies
using calf thymus DNA (CT-DNA). The apparent binding constants (Kapp) are of moderate values and
are 2.048 � 104 M�1 (±0.006) and 1.644 � 104 M�1 (±0.005), respectively. The modes of binding of the
complexes with CT-DNA has been investigated using circular dichroism, ethidium bromide displacement
assay and viscosity measurements. The cleavage properties of these complexes as well as the free proligand
with super coiled (SC) pUC19 are studied using the gel electrophoresis method, where both the
complexes displayed chemical nuclease activity in the presence of H2O2 via an oxidative mechanism.
The antimicrobial study using the free pro-ligand, 1 and 2 against both Gram positive and Gram negative
bacteria are performed, 2 showed antimicrobial activity against both Gram negative and Gram positive
bacteria whereas the free ligand and 1 show no antibacterial activity.
|
|
| Date |
2009
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/987/1/15_PH_2009.pdf
Banerjee, Sambuddha and Mondal , Susmita and Chakraborty, Writachit and Sen, Soma and Gachhui, Ratan and Ray, J Butcher and Slawin, Alexandra M Z and Mandal, Chitra and Mitra, Samiran (2009) Syntheses, X-ray Crystal Structures, DNA Binding, Oxidative Cleavage Activities and Antimicrobial Studies of Two Cu(II) Hydrazone Complexes. Polyhedron, 28 (13). pp. 2785-2793. |
|
| Relation |
http://dx.doi.org/:10.1016/j.poly.2009.05.071
http://www.eprints.iicb.res.in/987/ |
|