Efficient Synthesis of 3,3-diheteroaromatic Oxindole Analogues And Their in Vitro Evaluation For Spermicidal Potential
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Efficient Synthesis of 3,3-diheteroaromatic Oxindole Analogues And Their in Vitro Evaluation For Spermicidal Potential
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| Creator |
Paira, Priyankar
Hazra, Abhijit Kumar, Shrabanti Paira, Rupankar Sahu, Krishnendu B Naskar, Subhendu Saha, Pritam Mondal, Shyamal Maiti, Arindam Banerjee, Sukdeb Mondal, Nirup B |
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| Subject |
Chemistry
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| Description |
Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione
(isatin) with differently substituted indoles and pyrrole in presence of I2 in i-PrOH. The in vitro spermicidal
potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the
derivative, 3,3-bis (5-methoxy-1H-indol-3-yl) indolin-2-one (3d) exhibited most significant activity.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/990/1/21_BMCL_2009.pdf
Paira, Priyankar and Hazra, Abhijit and Kumar, Shrabanti and Paira, Rupankar and Sahu, Krishnendu B and Naskar, Subhendu and Saha, Pritam and Mondal, Shyamal and Maiti, Arindam and Banerjee, Sukdeb and Mondal, Nirup B (2009) Efficient Synthesis of 3,3-diheteroaromatic Oxindole Analogues And Their in Vitro Evaluation For Spermicidal Potential. Bioorganic & Medicinal Chemistry Letters, 19 (16). pp. 4786-4789. |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2009.06.049
http://www.eprints.iicb.res.in/990/ |
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