Evaluation of the Serum Catalase and Myeloperoxidase Activities in Chronic Arsenic-exposed Individuals and Concomitant Cytogenetic damage
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Evaluation of the Serum Catalase and Myeloperoxidase Activities in Chronic Arsenic-exposed Individuals and Concomitant Cytogenetic damage
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| Creator |
Banerjee, Mayukh
Banerjee, Nilanjana Ghosh, Pritha Das, Jayanta K Basu, Santanu Sarkar, Ajoy K States, J. Christopher Giri, Ashok K |
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| Subject |
Molecular & Human Genetics
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| Description |
Chronic arsenic exposure through contaminated drinking water is a major environmental health issue.
Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation
of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA
damage that might ultimately culminate in cancer. In order to keep the level of ROS in balance, an array of
enzymes is present, of which catalase (CAT) and myeloperoxidase (MPO) are important members. Hence, in
this study, we determined the activities of these two enzymes in the sera and chromosomal aberrations (CA)
in peripheral blood lymphocytes in individuals exposed and unexposed to arsenic in drinking water. Arsenic
in drinking water and in urine was used as a measure of exposure. Our results show that individuals
chronically exposed to arsenic have significantly higher CAT and MPO activities and higher incidence of CA.
We found moderate positive correlations between CAT and MPO activities, induction of CA and arsenic in
urine and water. These results indicate that chronic arsenic exposure causes higher CAT and MPO activities in
serum that correlates with induction of genetic damage. We conclude that the serum levels of these enzymes
might be used as biomarkers of early arsenic exposure induced disease much before the classical
dermatological symptoms of arsenicosis begin to appear.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1018/1/9_TAAP_2010.pdf
Banerjee, Mayukh and Banerjee, Nilanjana and Ghosh, Pritha and Das, Jayanta K and Basu, Santanu and Sarkar, Ajoy K and States, J. Christopher and Giri, Ashok K (2010) Evaluation of the Serum Catalase and Myeloperoxidase Activities in Chronic Arsenic-exposed Individuals and Concomitant Cytogenetic damage. Toxicology and Applied Pharmacology, 249 (1). pp. 47-54. |
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| Relation |
http://dx.doi.org/10.1016/j.taap.2010.08.013
http://www.eprints.iicb.res.in/1018/ |
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