A Novel Galacto-Glycerolipid from Oxalis Corniculata Kills Entamoeba Histolytica and Giardia Lamblia
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
A Novel Galacto-Glycerolipid from Oxalis Corniculata Kills
Entamoeba Histolytica and Giardia Lamblia
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| Creator |
Manna, Dipak
Dutta, Pradeep K Achari, Basudeb Lohia, Anuradha |
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| Subject |
Chemistry
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| Description |
Oxalis corniculata is a naturally occurring weed that has been used in traditional medicine for the cure of
dysentery and diarrhea in India. One of the common causes of dysentery is due to infection by the protist
pathogen Entamoeba histolytica. Bioactivity profiling of extracts from O. corniculata identified several compounds
that showed antiamoebic activity in axenic cultures of E. histolytica. These were characterized by
nuclear magnetic resonance, infrared, and mass spectrometry as (i) Oc-1, a mixture of saturated fatty acids C24
to C28; (ii) Oc-2, a mixture of long-chain alcohols C18 to C28; and (iii) Oc-3, a single compound that was a
galacto-glycerolipid (GGL). Of the different compounds that were obtained, the strongest antiamoebic activity
was found in GGL. The addition of GGL to E. histolytica xenic cultures containing other microbial flora from
the large intestine did not affect its antiamoebic activity. Amoebicidal concentrations of GGL had no effect on
intestinal microbial flora or on the mammalian cell line HEK-293. GGL was also found to be equally effective
in killing another protist pathogen, Giardia lamblia, that causes diarrhea in humans. The importance of this
study is based on the identification of novel natural products and the possibility of developing these compounds
as active agents to treat at least two pathogenic parasitic intestinal infections endemic to tropical regions.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1025/1/13_AAC_2010.pdf
Manna, Dipak and Dutta, Pradeep K and Achari, Basudeb and Lohia, Anuradha (2010) A Novel Galacto-Glycerolipid from Oxalis Corniculata Kills Entamoeba Histolytica and Giardia Lamblia. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54 (11). pp. 4825-4832. |
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| Relation |
http://dx.doi.org/10.1128/AAC.00546-10
http://www.eprints.iicb.res.in/1025/ |
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