Protein A – a new ligand for human C-reactive protein
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Protein A – a new ligand for human C-reactive protein
|
|
| Creator |
Das, Tanusree
Mandal, Chhabinath Mandal, Chitra |
|
| Subject |
Cancer Biology and Inflammatory Disorder Division
|
|
| Description |
Phosphorylcholine (PC) is a classical ligand of Creactive
protein (CRP), a clinically important acute phase
protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an
extended definition of CRP. Protein A binding may impart
immunomodulatory roles of CRP in combating microorganisms
or other foreign materials.
|
|
| Publisher |
Elsevier
|
|
| Date |
2004
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/1063/1/8_FL_2004.pdf
Das, Tanusree and Mandal, Chhabinath and Mandal, Chitra (2004) Protein A – a new ligand for human C-reactive protein. FEBS Letters, 576. pp. 107-113. |
|
| Relation |
http://dx.doi.org/10.1016/j.febslet.2004.08.072
http://www.eprints.iicb.res.in/1063/ |
|