Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer
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| Creator |
Bandyopadhyay, Uday
Biswas, Kaushik Sengupta, Arnab Moitra, Puspa Dutta, Prodip Sarkar, Dipankar Debnath, Pratip Ganguly, Chayan K Banerjee, Ranajit K |
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| Subject |
Cell Biology & Physiology
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| Description |
We have shown earlier that Neem (Azadirachta indica) bark aqueous extract has potent antisecretory and
antiulcer effects in animal models and has no significant adverse effect (Bandyopadhyay et al., Life Sciences, 71,
2845–2865, 2002). The objective of the present study was to investigate whether Neem bark extract had similar
antisecretory and antiulcer effects in human subjects. For this purpose, a group of patients suffering from acidrelated
problems and gastroduodenal ulcers were orally treated with the aqueous extract of Neem bark. The
lyophilised powder of the extract when administered for 10 days at the dose of 30 mg twice daily caused a
significant (p b 0.002) decrease (77%) in gastric acid secretion. The volume of gastric secretion and its pepsin
activity were also inhibited by 63% and 50%, respectively. Some important blood parameters for organ toxicity
such as sugar, urea, creatinine, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate
transaminase, albumin, globulin, hemoglobin levels and erythrocyte sedimentation rate remained close to the
control values. The bark extract when taken at the dose of 30–60 mg twice daily for 10 weeks almost completely
healed the duodenal ulcers monitored by barium meal X-ray or by endoscopy. One case of esophageal ulcer
(gastroesophageal reflux disease) and one case of gastric ulcer also healed completely when treated at the dose of
30 mg twice daily for 6 weeks. The levels of various blood parameters for organ toxicity after Neem treatment at
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| Publisher |
Elsevier
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| Date |
2004
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1067/1/6_LS_2004.pdf
Bandyopadhyay, Uday and Biswas, Kaushik and Sengupta, Arnab and Moitra, Puspa and Dutta, Prodip and Sarkar, Dipankar and Debnath, Pratip and Ganguly, Chayan K and Banerjee, Ranajit K (2004) Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sciences, 75. pp. 2867-2878. |
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| Relation |
http://dx.doi.org/10.1016/j.lfs.2004.04.050
http://www.eprints.iicb.res.in/1067/ |
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