A Polymorphism of the CREB Binding Protein (CREBBP) Gene is a Risk Factor for Addiction
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
A Polymorphism of the CREB Binding Protein (CREBBP) Gene is
a Risk Factor for Addiction
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| Creator |
Kumar, Deepak
Deb, Ishani Chakraborty, J Mukhopadhyay, Sikha Das, Sumantra |
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| Subject |
Cell Biology & Physiology
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| Description |
Unequivocal evidences have implicated c-AMP response element binding protein (CREB)
in drug addiction. Recent reports indicate that the CREB binding protein (CREBBP), a
transcription co-activator, may also be involved in the sensitivity to drugs of abuse. We
undertook studies on the single nucleotide polymorphisms (SNP) at selective areas of
CREBBP gene in heroin as well as in alcohol addicts and compared them with that in
normal population. One hundred fifty healthy controls, one hundred thirty heroin addict
and one hundred ten alcohol addicts, all males, Bengali-Hindu, and residing in Kolkata, a
city in eastern India, participated in the study. DNA prepared from blood drawn from the
subjects was PCR amplified for the regions corresponding to exon 3 and 22 of CREBBP
gene followed by sequencing. Three SNPs identified in the population were analyzed to
find out the association of these SNPs with addiction. One SNP, rs3025684 in intron 21
having the contig position of 3795363, showed association with addiction. The genotype
frequencies of the SNP were significantly different between opioid dependent cases and
controls (χ2=20.28, p<0.0001) as well as between alcoholics and controls (χ2=13.60,
p=0.0011). Our studies suggest that rs3025684 polymorphism may be a possible risk factor
for developing addiction.
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| Publisher |
Elsevier
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1069/1/2011%2DBRes.pdf
Kumar, Deepak and Deb, Ishani and Chakraborty, J and Mukhopadhyay, Sikha and Das, Sumantra (2011) A Polymorphism of the CREB Binding Protein (CREBBP) Gene is a Risk Factor for Addiction. Brain Research , 1406. pp. 59-64. |
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| Relation |
http://dx.doi.org/10.1016/j.brainres.2011.05.048
http://www.eprints.iicb.res.in/1069/ |
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