Synthesis and Biological Evaluation of Dibenz[b, f][1, 5]Oxazocine Derivatives for Agonist Activity at k-opioid Receptor
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synthesis and Biological Evaluation of Dibenz[b, f][1, 5]Oxazocine Derivatives for Agonist Activity at k-opioid Receptor
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| Creator |
Mitra, Sudipta
Banerjee, Tuhin Suvro Hota, Sandip K Bhattacharya, Debleena Das, Sumantra Chattopadhyay, Partha |
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| Subject |
Cell Biology & Physiology
Chemistry |
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| Description |
A short and high yield synthetic route to dibenz[b, f][1, 5]oxazocines has been developed using Pd
catalyzed intramolecular cycloamination reaction. Receptor binding assay using [125I]-dynorphin
demonstrated that one of the derivative, 5b showed selective k-opioidergic property.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1071/1/2011%2DEJMC.pdf
Mitra, Sudipta and Banerjee, Tuhin Suvro and Hota, Sandip K and Bhattacharya, Debleena and Das, Sumantra and Chattopadhyay, Partha (2011) Synthesis and Biological Evaluation of Dibenz[b, f][1, 5]Oxazocine Derivatives for Agonist Activity at k-opioid Receptor. European Journal of Medicinal Chemistry. pp. 1-8. |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2011.02.024
http://www.eprints.iicb.res.in/1071/ |
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