Nitric oxide donors protect against 1-methyl-4-phenyl pyridinium-induced experimental parkinsonism in rats: evidence for antioxida
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Nitric oxide donors protect against 1-methyl-4-phenyl
pyridinium-induced experimental parkinsonism in rats:
evidence for antioxida
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| Creator |
Banerjee, R
Sarvanan, K S Sindhu, Kizhake M Mohanakumar, K P |
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| Subject |
Cell Biology & Physiology
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| Description |
Nitric oxide (NO) with free radical properties plays a controversial critical
role under a variety of physiologic and pathologic conditions. We
investigated the effects of NO donors such as S-nitroso-N-acetylpenicillamine
(SNAP), 3-morpholinosydnonimine hydrochloride (SIN-1), sodium
nitroprusside (SNP) and nitroglycerin (NG) in nigrostriatal dopaminergic
toxicity caused by the potent parkinsonian neurotoxin, 1-methyl-4-phenylpyridinium
(MPP+) in vivo in rats and in MPP+ induced hydroxyl radical
(.OH) generation in mitochondria in vitro. NG, SNAP and SIN-1 caused
significant attenuation of MPP+ induced .OH generation in mitochondria.
Administration of MPP+ by intranigral infusion in rats to produce
nigrostriatal damage was significantly attenuated by co-infusion of NG,
SNAP and SIN-1 but not by SNP. NG, SNAP and SIN-1 exposed for 48 h to
remove NO when administered similarly, failed to protect against MPP+ induced neurotoxicity in vivo. Long-term exposed SNP when administered intranigrally, caused dose-dependent depletion of striatal dopamine. These results indicate that selective NO donors can protect dopaminergic neurotoxicity caused by MPP+ by releasing NO in the nigral region and by virtue of its OH scavenging action. This study warrants the neuroprotective
role of NO in dopaminergic neurodegeneration.
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| Date |
2003
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| Type |
Conference or Workshop Item
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1072/1/3_4_JN_2003.pdf
Banerjee, R and Sarvanan, K S and Sindhu, Kizhake M and Mohanakumar, K P (2003) Nitric oxide donors protect against 1-methyl-4-phenyl pyridinium-induced experimental parkinsonism in rats: evidence for antioxida. In: Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, WANCHAI, PEOPLES R CHINA. |
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| Relation |
http://onlinelibrary.wiley.com/doi/10.1046/j.1474-1644.2003.2175_9.x/pdf
http://www.eprints.iicb.res.in/1072/ |
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