L-deprenyl attenuates the rotenone-induced dopaminergic neurotoxicity: experimental evidences in rats
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
L-deprenyl attenuates the rotenone-induced
dopaminergic neurotoxicity: experimental evidences in
rats
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| Creator |
Sarvanan, K S
Sindhu, Kizhake M Mohanakumar, K P |
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| Subject |
Cell Biology & Physiology
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| Description |
Parkinson disease (PD) is progressive neurological disorder because of
massive degeneration of nigrostriatal dopaminergic neurons. The pathogenesis
of PD is unknown, but considerable evidence suggests multifactorial
factors including genetic, mitochondrial dysfunction, oxidative stress,
excitotoxicity, calcium cytotoxicity, environmental factors and apoptosis.
We investigated the role of oxidative damage produced by intranigral
infusion of a potent mitochondrial complex-I inhibitor, rotenone and studied
the neuroprotective effects with a well-known antiparkinsonian drug
L-deprenyl in rats. Unilateral stereotaxic intranigral infusion of rotenone
6 lg caused significant decrease in dopamine levels. L-deprenyl (10 mg/kg)
treatment significantly attenuated the DA depletion caused by rotenone.
Parallely, a significant decrease in the concentration of GSH was also
observed in the SN was reverted by L-deprenyl treatment. L-deprenyl
significantly attenuated the rotenone-induced decrease in tyrosine hydroxylase
immunoreactivity in striatum. The results suggest that L-deprenyl can
rescue the dopaminergic neurons from the rotenone mediated neurodegeneration
in this experimental animal model.
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| Date |
2003
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| Type |
Conference or Workshop Item
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1073/1/3_4_JN_2003.pdf
Sarvanan, K S and Sindhu, Kizhake M and Mohanakumar, K P (2003) L-deprenyl attenuates the rotenone-induced dopaminergic neurotoxicity: experimental evidences in rats. In: Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, WANCHAI, PEOPLES R CHINA. |
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| Relation |
http://onlinelibrary.wiley.com/doi/10.1046/j.1474-1644.2003.2175_9.x/pdf
http://www.eprints.iicb.res.in/1073/ |
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