Effect of acetylcholinesterase inhibitors in streptozotocin-induced Alzheimer’s disease in rats
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Effect of acetylcholinesterase inhibitors in
streptozotocin-induced Alzheimer’s disease in rats
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| Creator |
Hina, M
Mohanakumar, K P |
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| Subject |
Cell Biology & Physiology
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| Description |
Therapy of Alzheimer’s disease (AD) by acetylcholinesterase inhibitors has
brought in a host of problems because of its severe side effects including tremor.
Though anticholinesterases cause an increase in the level of acetylcholine in the
brain, other classes of neurotransmitters may also be affected. To understand the
extent of involvement of biogenic amine neurotransmitters in the actions of
anticholinestarase in AD, we investigated the effects of physostigmine and tacrine
in an animal model of the disease. Rats were administered intracerebroventricularly
with streptozotocin (STZ), and treated with physostigmine or tacrine. Discrete
brain regions such as nucleus caudate putamen (NCP) and hippocampus were
dissected and analyzed for the biogenic amines employing HPLC-electrochemistry.
Cognitive functions were assessed using a Plus-maze apparatus. Cholinesterase
activity increased significantly in striatum where as reduced in HP on 21st
day following STZ administration. While the cholinesterase inhibitor caused
severe inhibition of acetylcholinesterase in the striatum, heightened serotonin
levels were observed in the striatum and hippocampus. Initially after the STZ
injection, DA and 5-HT levels are reduced significantly on day 14, in NCP and HP.
DA level was increased significantly in both NCP and HP along with 5-HT in NCP
alone, on 21day following icv injection of STZ. Norepinephrine was unaffected.
Treatment with cholinesterase inhibitor in the STZ pretreated animals, compensates
the STZ-induced changes in DA and 5-HT in NCP as well as HP. The
behavioral and biochemical observations from the present study indicate the
neurochemical basis of the side effects (eg. tremor, hallucination, etc.) observed
following anticholinesterase therapy in AD.
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| Date |
2003
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| Type |
Conference or Workshop Item
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1074/1/3_4_JN_2003.pdf
Hina, M and Mohanakumar, K P (2003) Effect of acetylcholinesterase inhibitors in streptozotocin-induced Alzheimer’s disease in rats. In: oint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, WANCHAI, PEOPLES R CHINA. |
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| Relation |
http://onlinelibrary.wiley.com/doi/10.1046/j.1474-1644.2003.2175_9.x/pdf
http://www.eprints.iicb.res.in/1074/ |
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