Synchronous Modulation of Cell Surface Lectin and Its Receptor in a Homologous Cell Population: A Novel Mechanism of Cellular Regulation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synchronous Modulation of Cell Surface Lectin and Its Receptor in a Homologous Cell Population: A Novel Mechanism of Cellular Regulation
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| Creator |
Banerjee, Saswti
Dungdung, Sandhya Rekha Das, Kaushik Majumder, Gopal Chandra |
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| Subject |
Cell Biology & Physiology
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| Description |
Testicular immotile sperm undergo maturation during epididymal transit when these cells
pass through caput, corpus, and cauda-epididymal regions. Maturing goat spermatozoa
specifically at the distal corpus epididymal stage show head-to-head autoagglutination
when incubated in vitro in a modified Ringer's solution. Here, we show the biochemical
mechanism of autoagglutination event and its functional significance. A lectin-like
molecule located on sperm surface specifically interacts with its receptor of the
neighboring homologous cells to cause autoagglutination. Lectin is a Ca++-dependent
galactose-specific protein. Failure of the pre- and post-distal corpus sperm to show
autoagglutination is due to lack of lectin-like molecule and its receptors, respectively.
Maturing sperm at distal corpus stage acquire lectin-like molecule followed by sharp
disappearance of its receptor, and this event is synchronously associated with the initiation
of sperm forward motility that is essential for fertilization in vivo. Lectin and its receptor
isolated from sperm plasma membrane showed high efficacy for blocking autoagglutination
phenomenon. The data are consistent with the view that synchronous modulation of
homologous cell surface lectin and their receptors constitutes a novel mechanism for
cellular regulation by generating waves of signals by manipulating lectin–sugar-dependent
“self-talk” and cell–cell “cross-talk”.
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1088/1/EXPERIMENTAL_CELL_RESEARCH__Volume_312___Issue_12___Pages_2299%2D2308___[60].pdf
Banerjee, Saswti and Dungdung, Sandhya Rekha and Das, Kaushik and Majumder, Gopal Chandra (2006) Synchronous Modulation of Cell Surface Lectin and Its Receptor in a Homologous Cell Population: A Novel Mechanism of Cellular Regulation. Experimental Cell Research, 312 (12). pp. 2299-2308. |
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| Relation |
http://dx.doi.org/10.1016/j.yexcr.2006.03.020
http://www.eprints.iicb.res.in/1088/ |
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