Evidence of Direct Interactions Between the CC-Chemokines CCL3, CCL4 and CCL5 and Leishmania Promastigotes
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Evidence of Direct Interactions Between the CC-Chemokines
CCL3, CCL4 and CCL5 and Leishmania Promastigotes
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| Creator |
Roychoudhury, Kaushik
Dasgupta, Biplab Sen, Pradip Laskay, Tam'as Solbach, Werner De, Tripti Roy, Syamal |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Parasites of the genus Leishmania are very successful parasites, possessing multiple host evasive machineries and unique molecules that aid in their survival. It is presumed that a freshly inoculated parasite needs to survive in the hostile extracellular environment for several hours before it is internalized by a macrophage [1,2]. How the parasite survives within this extracellular environment and find their way to a macrophage are matters of great interest and enigma to clinicians and biologists alike. Chemotactic molecules secreted by the parasite, that are to
this day uncharacterized, can home certain host cells and probably play a major role in the process of inviting host cells to the site of infection [3]. Host derived chemotactic molecules, especially chemokines also play an important role in the homing of cells to the site of infection [4]. What is not clear is whether these host derived chemotactic factors can also be sensed and
utilized by the parasites.
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1089/1/MOLECULAR_AND_BIOCHEMICAL_PARASITOLOGY__Volume_150___Issue_2___Pages_374%2D377___[9].pdf
Roychoudhury, Kaushik and Dasgupta, Biplab and Sen, Pradip and Laskay, Tam'as and Solbach, Werner and De, Tripti and Roy, Syamal (2006) Evidence of Direct Interactions Between the CC-Chemokines CCL3, CCL4 and CCL5 and Leishmania Promastigotes. Molecular & Biochemical Parasitology, 150 (2). pp. 374-377. |
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| Relation |
http://dx.doi.org/10.1016/j.molbiopara.2006.08.009
http://www.eprints.iicb.res.in/1089/ |
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