A Rapid and Efficient Microwave-Assisted Synthesis of Substituted 3-Phenylpropionic Acids from Benzaldehydes in Minutes.
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
A Rapid and Efficient Microwave-Assisted Synthesis of Substituted 3-Phenylpropionic Acids from Benzaldehydes in Minutes.
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| Creator |
Sharma , A
Joshi, B P Sinha, Arun K |
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| Subject |
Nanotechnology
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| Description |
A convenient, inexpensive, and efficient synthesis of 3-phenylpropionic acids (1a–1f) by reacting benzaldehyde (2a–2f) and malonic acid in acetic acid and piperidine into cinnamic acid (3a–3f) in 77 to 89% followed by its reduction with PdCl2 in the biphase of formic acid and aqueous sodium hydroxide is reported under microwave irradiation which utilizes short reaction time ranging 5 to 7 min to provide 1a–1f in moderate to high yield (69–86%) depending upon methoxy, methylenedioxy, and hydroxy groups present at the phenyl ring.
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| Publisher |
The Chemical Society of Japan
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| Date |
2003
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| Type |
Article
PeerReviewed |
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| Relation |
http://www.csj.jp/journals/chem-lett/index.html
http://ihbt.csircentral.net/720/ |
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| Identifier |
Sharma , A and Joshi, B P and Sinha, Arun K (2003) A Rapid and Efficient Microwave-Assisted Synthesis of Substituted 3-Phenylpropionic Acids from Benzaldehydes in Minutes. Chemistry Letters, 32 (12). pp. 1186-67. ISSN 0366-7022
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