Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats
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| Creator |
Singh, Surjeet
Khajuria, Anamika Taneja, Subhash Chandra Khajuria, Ravi Kant Singh, Jaswant Qazi, Ghulam Nabi |
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| Subject |
Pharmacological Sciences
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| Description |
The present study revealed the synergistic effect of boswellic acid mixture (BA) and glucosamine for anti-inflammatory and anti-arthritic activities in rats. Two studies were conducted, that is, acute anti-inflammatory by carrageenan edema and chronic
anti-arthritic by Mycobacterium-induced developing arthritis. Five groups of animals were included in each of the study: the vehicle control, positive control (ibuprofen 100 mg/kg), boswellic acids (250 mg/kg), glucosamine (250 mg/kg) and a combination of boswellic acids (125 mg/kg) and glucosamine (125 mg/kg). BA when administered at 250 mg/kg in rats, carrageenan-induced paw edema and Mycobacterium-induced developing arthritis were significantly inhibited. In comparison to boswellic acids, glucosamine when
administered at 250 mg/kg showed a mild effect in carrageenan-induced edema and moderate inhibition of paw swelling against developing arthritis. Although the combination of boswellic acids and glucosamine did not affect the acute inflammation to a greater extent yet a significant anti-arthritic activity was observed in rats. In conclusion, a synergistic effect was observed in chronic inflammatory conditions when two chemical entities were administered in combination in preclinical study.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/224/1/10.1016j.bmcl.2007.04.034.pdf
Singh, Surjeet and Khajuria, Anamika and Taneja, Subhash Chandra and Khajuria, Ravi Kant and Singh, Jaswant and Qazi, Ghulam Nabi (2007) Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats. Bioorganic & Medicinal Chemistry Letters, 17 (13). pp. 3706-3711. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2007.04.034
http://iiim.csircentral.net/224/ |
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