Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders
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| Creator |
Singh, S.
Khajuria, A. Taneja, S.C. Johri, R.K. Singh, J. Qazi, G.N. |
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| Subject |
Pharmacological Sciences
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| Description |
Boswellic acids (BA), a natural mixture isolated from oleo gum resin of Boswellia serrata comprised of four major
pentacyclic triterpene acids: b-boswellic acid (the most abundant), 3-acteyl-b-boswellic acid, 11-keto-b-boswellic acid,and 3-acetyl-11-keto-b-boswellic acid, is reported to be effective as anti-inflammatory, immunomodulatory, antitumor,anti-asthmatic and in Chron’s disease. It inhibits pro-inflammatory mediators in the body, specifically leukotrienes via inhibition of 5-lipoxygenase, the key enzyme of leukotriene synthesis, is the scientifically proved mechanism for its anti-inflammatory/anti-arthritic activity. All previous work on BA for its biological activity has been done through the systemic application but no pre-clinical data reported for its anti-inflammatory activity by topical
application. We here by report anti-inflammatory activity of BA through this route by applying different acute and
chronic models of inflammation i.e., arachidonic acid and croton oil-induced mouse ear edema, carrageenan-induced
rats paw edema and adjuvant-induced developing arthritis in rats. The results of the study revealed that the effect
observed through this route is in accordance to the study conducted with the systemic route, thus establishing that BA
when used through topical application is as effective as through the systemic route.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/226/1/10.1016j.phymed.2007.11.019.pdf
Singh, S. and Khajuria, A. and Taneja, S.C. and Johri, R.K. and Singh, J. and Qazi, G.N. (2008) Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders. Phytomedicine, 15 (6-7). pp. 400-407. ISSN 09447113 |
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| Relation |
http://dx.doi.org/10.1016/j.phymed.2007.11.019
http://iiim.csircentral.net/226/ |
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