Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis
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| Creator |
Singh, Shashank Kumar
Bhusari, Sachin Singh, Reena Saxena, Ajit Mondhe, Dilip Qazi, Ghulam Nabi |
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| Subject |
Pharmacological Sciences
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| Description |
Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto β-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel+bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto β-boswellic acids (10 mg/kg/d) inhibited the Matrigel+bFGF-induced angiogenesissignificantly (Pb0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/244/1/10.1016j.vph.2006.09.008.pdf
Singh, Shashank Kumar and Bhusari, Sachin and Singh, Reena and Saxena, Ajit and Mondhe, Dilip and Qazi, Ghulam Nabi (2007) Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis. Vascular Pharmacology, 46 (5). pp. 333-337. ISSN 15371891 |
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| Relation |
http://dx.doi.org/10.1016/j.vph.2006.09.008
http://iiim.csircentral.net/244/ |
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