Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one
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| Creator |
Youssouf, M.S.
Kaiser, P. Singh, G.D. Singh, S. Bani, S. Gupta, V.K. Satti, N.K. Suri, K.A. Johri, R.K. |
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| Subject |
Pharmacological Sciences
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| Description |
An immunopharmacological profile of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one(P-I) has been investigated using in vitro and in vivo models representing various features of Type I allergy. P-I prevented compound 48/80-mediated histamine release from rat peritoneal mast
cells. A promising anti-inflammatory activity of P-I was evident in active paw anaphylaxis (mice)and carragenan-induced paw edema (rat). P-I inhibited eosonophil accumulation and eosinophil peroxidase activity in bronchoalveolar lavage fluid from ovalbumin challenged balb/c mice: in these animals blood levels of IL-5, and CD4+ T cells also remained attenuated. A promising
bronchorelaxant effect of P-I was observed in histamine-contracted guinea pig tracheal chain via its antagonism to H1 receptor. These findings were compared with some known compounds(ketotifen, cetirizine and promethazine). The anti-histaminic, anti-inflammatory and bronchorelaxant
activities of P-I has been discussed in context with its potential profile as an anti-allergic and anti-asthmatic agent.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/212/1/10.1016j.intimp.2008.03.015.pdf
Youssouf, M.S. and Kaiser, P. and Singh, G.D. and Singh, S. and Bani, S. and Gupta, V.K. and Satti, N.K. and Suri, K.A. and Johri, R.K. (2008) Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one. International Immunopharmacology, 8 (7). pp. 1049-1055. ISSN 15675769 |
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| Relation |
http://dx.doi.org/10.1016/j.intimp.2008.03.015
http://iiim.csircentral.net/212/ |
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