Investigations of regio- and stereoselectivities in the synthesis of cytotoxic isoxazolidines through 1,3-dipolar cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Investigations of regio- and stereoselectivities in the synthesis of cytotoxic isoxazolidines through 1,3-dipolar cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen
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| Creator |
Singh, Rajinder
Bhella, Surinderjit Singh Sexana, A.K. Shanmugavel, M. Faruk, Abdul Ishar, M.P.S. |
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| Subject |
Chemical Sciences
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| Description |
Abstract—Regio- and stereoselectivities in cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen, which furnishes substituted-isoxazolidine analogs of the furanose ring of nucleosides, have been investigated. Although the obtained regioselectivities are anticipated, a rationalization of the preferred formation of endo-cycloadducts necessitates the involvement of an allylic oxygen in secondary interaction. The obtained isoxazolidines display cytotoxic activities against a number of human cancer cell lines.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/279/1/10.1016j.tet.2006.12.076.pdf
Singh, Rajinder and Bhella, Surinderjit Singh and Sexana, A.K. and Shanmugavel, M. and Faruk, Abdul and Ishar, M.P.S. (2007) Investigations of regio- and stereoselectivities in the synthesis of cytotoxic isoxazolidines through 1,3-dipolar cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen. Tetrahedron, 63 (10). pp. 2283-2291. ISSN 00404020 |
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| Relation |
http://dx.doi.org/10.1016/j.tet.2006.12.076
http://iiim.csircentral.net/279/ |
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