Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
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| Creator |
Kamal, Ahmed
Shetti, Rajesh V.C.R.N.C. Azeeza, Shaik Ahmed, S. Kaleem Swapna, P. Reddy, A. Malla Khan, Inshad Ali Sharma, Sandeep Abdullah, Sheikh Tasduq |
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| Subject |
Pharmacological Sciences
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| Description |
In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine
1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC ΒΌ 1 mg/mL) is also discussed.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/214/1/10.1016j.ejmech.2010.07.015.pdf
Kamal, Ahmed and Shetti, Rajesh V.C.R.N.C. and Azeeza, Shaik and Ahmed, S. Kaleem and Swapna, P. and Reddy, A. Malla and Khan, Inshad Ali and Sharma, Sandeep and Abdullah, Sheikh Tasduq (2010) Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. European Journal of Medicinal Chemistry, 45 (10). pp. 4545-4553. ISSN 02235234 |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2010.07.015
http://iiim.csircentral.net/214/ |
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