Immunomodulation exhibited by piperinic acid through suppression of proinflammatory cytokines
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Immunomodulation exhibited by piperinic acid through suppression of proinflammatory cytokines
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| Creator |
Devan, Prabhavathy
Bani, Sarang Suri, Krishna Avtar Satti, Naresh Kumar Qazi, Ghulam Nabi |
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| Subject |
Pharmacological Sciences
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| Description |
Piper longum (PL) has been reported for its varied pharmacological activities including bio-enhancer and anti-inflammatory activities in traditional medicine. Here the premise of the study was to investigate the immunoregulatory potential of PL and piperinic acid, one of its active constituent, in Balb/C mice (in vivo) and human PBMCs (in vitro) models. Piperinic acid moderated the proinflammatory mediators and cytokines in our experiments. At doses of 10, 20, 40 and 80 mg/kg p.o. PL showed a dose
dependent decrease of lymphocytes (CD4+ and CD8+ T cells) and cytokine levels in sensitized Balb/C mice with a marked
inhibition at 40 mg/kg. At an in vitro dose of 20 μg/ml of PL and 5 μg/ml of piperinic acid, there was a significant inhibition of mitogen induced human PBMC proliferation, mRNA transcripts of IL-2 (ConA) and TNFα, IL-1β and iNOS (LPS) respectively under stimulated conditions in time dependent (6 h, 12 h and 24 h respectively) expression studies. In parallel, induced nitric oxide production was also reduced by stimulated macrophages. Our observations rationalize the traditional use of PL and also validate the
immunoregulatory potential of piperinic acid.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/264/1/10.1016j.intimp.2007.02.008.pdf
Devan, Prabhavathy and Bani, Sarang and Suri, Krishna Avtar and Satti, Naresh Kumar and Qazi, Ghulam Nabi (2007) Immunomodulation exhibited by piperinic acid through suppression of proinflammatory cytokines. International Immunopharmacology, 7 (7). pp. 889-899. ISSN 15675769 |
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| Relation |
http://dx.doi.org/10.1016/j.intimp.2007.02.008
http://iiim.csircentral.net/264/ |
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