Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones
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| Creator |
Kamal, Ahmed
Shetti, Rajesh V.C.R.N.C. Azeeza, Shaik Swapna, P. Khan, M. Naseer A. Khan, Inshad Ali Sharma, Sandeep Abdullah, Sheikh Tasduq |
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| Subject |
Chemical Sciences
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| Description |
As a part of investigation of new anti-tubercular agents in this laboratory, herein we describe the synthesis of a newclass of arylsulfonamido conjugated oxazolidinones. The in vitro activity of these conjugated (6aef,7aed, 9aec and 11aec) molecules against Mycobacterium tuberculosis H37Rv by using rifampicin and linezolide as positive controls is discussed, compounds 7c and 9aec are found to be the most active members in this series. Further, cytotoxicity of the potent conjugates of the series (7c, and 9aec) was
evaluated on human foreskin fibroblast (HFF) cells by using MTT assay. Finally, these studies suggest that compounds 7c and 9a mayserve as promising lead scaffolds for further generation of newas anti-TB agents.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/215/1/10.1016j.ejmech.2010.12.028.pdf
Kamal, Ahmed and Shetti, Rajesh V.C.R.N.C. and Azeeza, Shaik and Swapna, P. and Khan, M. Naseer A. and Khan, Inshad Ali and Sharma, Sandeep and Abdullah, Sheikh Tasduq (2011) Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones. European Journal of Medicinal Chemistry, 46 (3). pp. 893-900. ISSN 02235234 |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2010.12.028
http://iiim.csircentral.net/215/ |
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