Citral derived amides as potent bacterial NorA efflux pump inhibitors
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Citral derived amides as potent bacterial NorA efflux pump inhibitors
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| Creator |
Thota, Niranjan
Koul, Surrinder Reddy, Mallepally V. Sangwan, Payare L. Khan, Inshad A. Kumar, Ashwani Raja, Alsaba F. Andotra, Samar S. Qazi, Ghulam N. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
Monoterpene citral and citronellal have been used as starting material for the preparation of 5,9- dimethyl-deca-2,4,8-trienoic acid amides and 9-formyl-5-methyl-deca-2,4,8-trienoic acid amides. The amides on bioevaluation as efflux pump inhibitors (EPIs) against Staphylococcus aureus 1199 and NorA overexpressing S. aureus 1199B bacteria resulted in the identification of several of these as potent EPIs. Many of these amides have been shown to possess potency higher or equivalent to known EPIs such as reserpine, verapamil, carsonic acid, and piperine. In this communication, we report a convenient synthesis of alkenyl amides, their bioevaluation and identification as efflux pump inhibitors against S. aureus.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/231/1/10.1016j.bmc.2008.05.030.pdf
Thota, Niranjan and Koul, Surrinder and Reddy, Mallepally V. and Sangwan, Payare L. and Khan, Inshad A. and Kumar, Ashwani and Raja, Alsaba F. and Andotra, Samar S. and Qazi, Ghulam N. (2008) Citral derived amides as potent bacterial NorA efflux pump inhibitors. Bioorganic & Medicinal Chemistry, 16 (13). pp. 6535-6543. ISSN 09680896 |
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| Relation |
http://dx.doi.org/10.1016/j.bmc.2008.05.030
http://iiim.csircentral.net/231/ |
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