Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum
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| Creator |
Goswami, Abhishek
Saikia, Partha P. Barua, Nabin C. Bordoloi, Manobjyoti Yadav, Archana Bora, Tarun C. Gogoi, Binod K. Saxena, Ajit Kumar Suri, Nithasa Sharma, Madhunika |
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| Subject |
Pharmacological Sciences
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| Description |
Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using
soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS–MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/223/1/10.1016j.bmcl.2009.10.097.pdf
Goswami, Abhishek and Saikia, Partha P. and Barua, Nabin C. and Bordoloi, Manobjyoti and Yadav, Archana and Bora, Tarun C. and Gogoi, Binod K. and Saxena, Ajit Kumar and Suri, Nithasa and Sharma, Madhunika (2010) Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum. Bioorganic & Medicinal Chemistry Letters, 20 (1). pp. 359-361. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2009.10.097
http://iiim.csircentral.net/223/ |
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