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Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice

IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu


Field	Value

Title	Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice

Creator	Kumar, H.M. Sampath Singh, Parvinder Pal Qazi, Naveed A. Srinivas, Jada Malik, Fayaz Sidiq, Tabasum Gupta, Amit Khajuria, Anamika Suri, K.A. Satti, N.K. Qazi, G.N.

Subject	Chemical Sciences

Description	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-�) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8). Furthermore, these modified analogs of picroside-II were able to elicit a substantial increase in anti-OVA IgG when compared with OVA alone. These results support the use of acylated analogs particularly PK-II-3 and PK-II-4 as potent enhancer of antigen-specific Th1 and Th2 immune responses and thus are promising immune-adjuvant candidate for vaccines.

Date	2010

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://iiim.csircentral.net/239/1/10.1016j.vaccine.2010.07.062.pdf Kumar, H.M. Sampath and Singh, Parvinder Pal and Qazi, Naveed A. and Srinivas, Jada and Malik, Fayaz and Sidiq, Tabasum and Gupta, Amit and Khajuria, Anamika and Suri, K.A. and Satti, N.K. and Qazi, G.N. (2010) Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice. Vaccine, 28 (52). pp. 8327-8337. ISSN 0264410X

Relation	http://dx.doi.org/10.1016/j.vaccine.2010.07.062 http://iiim.csircentral.net/239/