Microwave-assisted rapid synthesis of methyl 2,4,5-trimethoxyphenylpropionate, a metabolite of Cordia alliodora
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
Microwave-assisted rapid synthesis of methyl 2,4,5-trimethoxyphenylpropionate, a metabolite of Cordia alliodora
|
|
| Creator |
Sinha, Arun K
Joshi, B P Sharma, A Kumar, J K Kaul , V K |
|
| Subject |
Natural Product Chemistry
|
|
| Description |
Microwave assisted condensation of asaronaldehyde (2) with malonic acid in piperidine-AcOH provides 2,4,5-trimethoxycinnamic acid (3) in 87% yield within 4 min, which upon further reduction with PdCl2-HCOOH-aq. NaOH gives 3-(2,4,5-trimethoxy) phenyl propionic acid (4) in 88% yield within 3 min. Esterification of 4 with MeOH-H+ gives methyl 2,4,5-trimethoxyphenylpropionate (1), a metabolite of Cordia alliodora, in 94% yield within 3 min (overall 69% yield).
|
|
| Publisher |
Taylor & Francis Ltd, 4 Park Square, Milton Park, Abingdon OX14 4RN, Oxon, England
|
|
| Date |
2003
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://ihbt.csircentral.net/376/1/106_2003_Microwave.pdf
Sinha, Arun K and Joshi, B P and Sharma, A and Kumar, J K and Kaul , V K (2003) Microwave-assisted rapid synthesis of methyl 2,4,5-trimethoxyphenylpropionate, a metabolite of Cordia alliodora. Natural Product Research, 17 (6). pp. 419-422. ISSN 1478-6419 |
|
| Relation |
http://ihbt.csircentral.net/376/
|
|